Know more about all the Janssen COVID-19 vaccine (ingredients, side effect and how it work) Part 4

 

This is my fourth blog on COVID19 vaccine. In this one, I will give you more information about Janssen COVID-19 vaccine.

The Janssen COVID-19 vaccine (Ad26.COV2.S) is use to prevent COVID-19. This disease is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).The vaccine is approved for people who are 18 years of age and older. Its safety and effectiveness in people younger than 18 years of age have not yet been establish. Health Canada authorized this vaccine with conditions on March 5, 2021, under the interim order respecting the importation, sale and advertising of drugs for use in relation to COVID-19.

 

Ingredients

Medicinal ingredient

adenovirus vector vaccine

Non-medicinal ingredients

2-hydroxypropyl-β-cyclodextrin (HBCD)

citric acid monohydrate

ethanol

hydrochloric acid

polysorbate-80

sodium chloride

sodium hydroxide

trisodium citrate dehydrate

water for injection

How it works

Viral vector-based vaccines use a harmless virus, such as an adenovirus, as a delivery system. This “vector” virus is not the virus that causes COVID-19. Adenoviruses are among the viruses that can cause the common cold. There are many different types of adenoviruses, and many have been used as delivery systems for other vector-based vaccines for decades.

When a person is given the vaccine, the vector virus contained within the vaccine produces the SARS-CoV-2 spike protein, which is found on the surface of the virus that causes COVID-19. This rotein will not make you sick. It does its job and goes away.

Through this process, the body is able to build a strong immune response against the spike protein without exposing you to the virus that causes COVID-19.

How it’s given

A single 0.5mL dose of the vaccine is given by injection into the muscle of the arm.

Based on studies in about 43,000 participants, the Janssen COVID-19 vaccine was 66% effective in preventing symptomatic COVID-19 disease beginning 2 weeks after vaccination. Immunity develops over time. You won’t develop significant protection against COVID-19 for at least 2 weeks.

 

Possible side effects

In general, the side effects observed during the clinical trials are similar to what you might have with other vaccines. The side effects that followed vaccine administration in clinical trials were mild or moderate. They included things like pain at the site of injection, body chills, feeling tired and feeling feverish.

These are common side effects of vaccines and do not pose a risk to health.

As with all vaccines, there’s a chance that there will be a serious side effect, but these are rare. A serious side effect might be something like an allergic reaction. Speak with your health professional about any serious allergies or other health conditions you may have before you receive this vaccine.

Health Canada has conducted a rigorous scientific review of the available medical evidence to assess the safety of the Janssen COVID-19 vaccine. No major safety concerns have been identified in the data that we reviewed